SPM Specialized Pro-Resolving Mediators

Nutritional Frontiers SPM is a unique, SPM omega-3 derived supplement designed to help modulate and resolve inflammation. SPM stands for "Specialized Pro-resolving Mediators" which are recently discovered, naturally occurring substances derived from omega-3 and omega-6 fatty acids. Our bodies make SPMs as a response to help resolve inflammation and they can be produced all over the body. Specialized pro-resolving mediators are theorized to contribute to the demonstrable beneficial effects of omega-3 fatty acids on reducing inflammation.

SPMs do not block the vital initial inflammatory response to trauma, but rather SPMs prevent excessive inflammation and promote tissue homeostasis (return to normal functioning) by controlling the duration and magnitude of inflammation. They are called 'resolving mediators' because of their role in facilitating natural resolution of the inflammatory response. Examples of SPMs include resolvins, lipoxins, protectins, and maresins. SPMs have demonstrated potent immunoregulatory and anti-inflammatory activities such as inhibiting the production of pro-inflammatory mediators and regulating white blood cells. In addition to actively resolving inflammation, SPMs protect organs and stimulate tissue regeneration.

While SPMs are produced naturally in humans, the ability of the body to produce SPMs may be compromised in the setting of obesity and aging. Since SPMs are involved in the active, regulated process of resolving acute inflammation and managing the return to tissue homeostasis, supplementing with SPMs may provide benefit and relief to those individuals struggling with discomfort and prolonged inflammation.